Xanthones from the stems of Cudrania tricuspidata and their inhibitory effects on pancreatic lipase and fat accumulation

Bioorg Chem. 2019 Nov:92:103234. doi: 10.1016/j.bioorg.2019.103234. Epub 2019 Aug 29.

Abstract

Nine new xanthones, cudracuspixanthones I - Q (12-14, 25, 32-36), and 30 known xanthones (1-11, 15-24, 26-31, 37-39) were isolated from the stems of Cudrania tricuspidata (Moraceae). The structures of isolated compounds were established by using 1D and 2D NMR in combination with HR-TOF-MS. Xanthones from the stems of C. tricuspidata exerted pancreatic lipase inhibitory activity. In addition, cudracuspixanthone P (35), a new xanthone, reduced the fat accumulation in liver cells stimulated with fatty acids. Therefore, these compounds might be beneficial in the treatment of metabolic diseases.

Keywords: Cudracuspixanthones I - Q; Cudrania tricuspidata; Fat accumulation; Moraceae; Pancreatic lipase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hep G2 Cells
  • Humans
  • Lipase / antagonists & inhibitors*
  • Lipid Metabolism / drug effects*
  • Molecular Structure
  • Moraceae / chemistry*
  • Pancreas / drug effects*
  • Pancreas / embryology
  • Plant Extracts / chemistry
  • Plant Stems / chemistry*
  • Triglycerides / metabolism
  • Xanthones / chemistry
  • Xanthones / isolation & purification
  • Xanthones / pharmacology*

Substances

  • Plant Extracts
  • Triglycerides
  • Xanthones
  • Lipase