With a digital revolution impacting nearly all industries and disciplines, the incorporation of digital technologies into dental offices and laboratories appears to be inevitable. Highlighting the use of computer-aided design/computer-aided manufacturing (CAD/CAM) technology, this case report demonstrates the development of a maxillofacial prosthesis after creation of a 3-dimensional printed surgical guide to enable accurate and predictable implant positioning to enhance overall facial prosthetic retention and comfort for the patient. The management of lost craniofacial hard and soft tissues due to congenital abnormalities, trauma, or, in this case, cancer treatment poses a multifaceted challenge to not only oral and maxillofacial surgeons but also general dentists, prosthodontists, dental laboratory technicians, and other dental and medical professionals. CAD/CAM technology may be viewed beyond its use for teeth reconstructions and intraoral implants and become an important tool for success when implant-supported maxillofacial prosthetic components are needed.