Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care

Zihan Li; Luca Leustean; Fatih Inci; Min Zheng; Utkan Demirci; Shuqi Wang

doi:10.1016/j.biotechadv.2019.107440

Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care

Biotechnol Adv. 2019 Dec;37(8):107440. doi: 10.1016/j.biotechadv.2019.107440. Epub 2019 Aug 30.

Authors

Zihan Li¹, Luca Leustean¹, Fatih Inci², Min Zheng³, Utkan Demirci⁴, Shuqi Wang⁵

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China; Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310029, China; University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada.
² Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA 94304, USA.
³ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China. Electronic address: minzheng@zju.edu.cn.
⁴ Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA 94304, USA; Department of Electrical Engineering (by courtesy), Stanford University, Stanford, CA 94305, USA. Electronic address: utkan@stanford.edu.
⁵ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China; Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310029, China. Electronic address: shuqi@zju.edu.cn.

PMID: 31476421
DOI: 10.1016/j.biotechadv.2019.107440

Abstract

Infectious diseases such as HIV-1/AIDS, tuberculosis (TB), hepatitis B (HBV), and malaria still exert a tremendous health burden on the developing world, requiring rapid, simple and inexpensive diagnostics for on-site diagnosis and treatment monitoring. However, traditional diagnostic methods such as nucleic acid tests (NATs) and enzyme linked immunosorbent assays (ELISA) cannot be readily implemented in point-of-care (POC) settings. Recently, plasmonic-based biosensors have emerged, offering an attractive solution to manage infectious diseases in the developing world since they can achieve rapid, real-time and label-free detection of various pathogenic biomarkers. Via the principle of plasmonic-based optical detection, a variety of biosensing technologies such as surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), colorimetric plasmonic assays, and surface enhanced Raman spectroscopy (SERS) have emerged for early diagnosis of HIV-1, TB, HBV and malaria. Similarly, plasmonic-based colorimetric assays have also been developed with the capability of multiplexing and cellphone integration, which is well suited for POC testing in the developing world. Herein, we present a comprehensive review on recent advances in surface chemistry, substrate fabrication, and microfluidic integration for the development of plasmonic-based biosensors, aiming at rapid management of infectious diseases at the POC, and thus improving global health.

Keywords: Biosensor; Detection; Diagnosis; Infectious disease; Optical sensors; Plasmonic; Point-of-care.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques*
Communicable Diseases*
Humans
Point-of-Care Systems
Spectrum Analysis, Raman
Surface Plasmon Resonance