Effect of alpha-NETA on auditory event related potentials in sensory gating study paradigm in mice

Neurosci Lett. 2019 Nov 1:712:134470. doi: 10.1016/j.neulet.2019.134470. Epub 2019 Aug 30.

Abstract

The potential contribution of trace amines (TA) to the pathophysiology of neuropsychiatric disorders makes it interesting to examine the effect of TA receptor ligands on schizophrenia biomarkers. We studied the effect of systemic administration of a putative Trace Amine-Associated Receptor 5 (TAAR5) agonist, alpha-NETA (2-(alpha-naphthoyl) ethyltrimethylammonium iodide), on the amplitude of the N40 event related potentials component and on the sensory gating (SG) index in C57BL/6 mice. It was found that low doses of alpha-NETA (2.5 mg/kg and 5 mg/kg) do not elicit a significant effect on the parameters of the N40 component and the SG index. However, the higher dose of alpha-NETA (10 mg/kg) induces a significant effect on the N40 component, but since a decrease in amplitude is observed on both the first and second stimuli in the pair, the SG index does not change. Thus, alpha-NETA administration causes a steady decrease in the N40 amplitude in response to both the first and second stimuli in the paired-click paradigm, and an increase in the N40 peak latency.

Keywords: Alpha-NETA; Event related potentials; N40; Sensory gating; TAAR5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Auditory Cortex / drug effects*
  • Electroencephalography
  • Evoked Potentials, Auditory / drug effects*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Naphthalenes / pharmacology*
  • Quaternary Ammonium Compounds / pharmacology*
  • Sensory Gating / drug effects*

Substances

  • Naphthalenes
  • Quaternary Ammonium Compounds
  • 2-naphthoylethyltrimethylammonium