Caffeine not associated with irritable behaviour in very low-birth-weight infants

Tomoki Maeda; Kazuhito Sekiguchi; Rieko Wasada; Kenji Ihara

doi:10.1016/j.earlhumdev.2019.104835

Caffeine not associated with irritable behaviour in very low-birth-weight infants

Early Hum Dev. 2019 Oct:137:104835. doi: 10.1016/j.earlhumdev.2019.104835. Epub 2019 Aug 29.

Authors

Tomoki Maeda¹, Kazuhito Sekiguchi², Rieko Wasada², Kenji Ihara²

Affiliations

¹ Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan. Electronic address: tmaeda@oita-u.ac.jp.
² Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.

PMID: 31473373
DOI: 10.1016/j.earlhumdev.2019.104835

Abstract

This paper is an examination of irritable behaviour in very low-birth-weight infants in relation to caffeine or aminophylline. We assessed tremulous movement (a sub-score of General Movements Optimality Score) in 18 caffeine-treated subjects and 18 aminophylline-treated subjects. Caffeine, unlike aminophylline, was not associated with irritable behaviour at standard dose.

Keywords: Aminophylline; Apnea of prematurity; Behaviour; Caffeine; General Movements; Methylxanthine; Tremulous movements.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminophylline / administration & dosage
Aminophylline / adverse effects
Aminophylline / therapeutic use
Apnea / drug therapy
Bronchodilator Agents / administration & dosage
Bronchodilator Agents / adverse effects
Bronchodilator Agents / therapeutic use
Caffeine / administration & dosage
Caffeine / adverse effects*
Caffeine / therapeutic use
Central Nervous System Stimulants / administration & dosage
Central Nervous System Stimulants / adverse effects*
Central Nervous System Stimulants / therapeutic use
Female
Humans
Infant Behavior*
Infant, Newborn
Infant, Premature, Diseases / drug therapy
Infant, Very Low Birth Weight / physiology*
Irritable Mood*
Male
Movement

Substances

Bronchodilator Agents
Central Nervous System Stimulants
Aminophylline
Caffeine