Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158520. doi: 10.1016/j.bbalip.2019.158520. Epub 2019 Aug 29.

Abstract

Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

Keywords: Fatty acids; Jasmonate; Oxylipin; Phytohormone; ω-Hydroxylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / growth & development
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / metabolism*
  • Cyclopentanes / metabolism*
  • Hydroxylation
  • Isoleucine / analogs & derivatives*
  • Isoleucine / metabolism
  • Molecular Docking Simulation
  • Oxylipins / metabolism
  • Plant Growth Regulators / metabolism
  • Repressor Proteins / metabolism*
  • Signal Transduction*

Substances

  • ASK1 protein, Arabidopsis
  • Arabidopsis Proteins
  • COI1 protein, Arabidopsis
  • Cyclopentanes
  • JAZ1 protein, Arabidopsis
  • Oxylipins
  • Plant Growth Regulators
  • Repressor Proteins
  • jasmonoyl-isoleucine
  • Isoleucine
  • jasmonic acid