X-nuclei hyperpolarization for studying molecular dynamics by DNP-FFC

Bulat Gizatullin; Carlos Mattea; Siegfried Stapf

doi:10.1016/j.jmr.2019.106583

X-nuclei hyperpolarization for studying molecular dynamics by DNP-FFC

J Magn Reson. 2019 Oct:307:106583. doi: 10.1016/j.jmr.2019.106583. Epub 2019 Aug 23.

Authors

Bulat Gizatullin¹, Carlos Mattea¹, Siegfried Stapf²

Affiliations

¹ FG Technische Physik II/Polymerphysik, Technische Universität Ilmenau, D-98684 Ilmenau, Germany.
² FG Technische Physik II/Polymerphysik, Technische Universität Ilmenau, D-98684 Ilmenau, Germany. Electronic address: Siegfried.Stapf@tu-ilmenau.de.

PMID: 31472437
DOI: 10.1016/j.jmr.2019.106583

Abstract

Dynamic Nuclear Polarization methods are used for improving the quality of the NMR data, opening new possibilities by increasing both the sensitivity and the selectivity in NMR relaxation experiments. Recently, Fast Field Cycling relaxometry combined with DNP was introduced, demonstrating that molecular dynamics studies in the presence of natural or artificial radicals are indeed feasible under conditions where the signal-to-noise ratio is frequently critical. In this work, the extension of NMR relaxation dispersion beyond ¹H NMR, by hyperpolarization of X-nuclei, is demonstrated. Overhauser effect via nitroxide radicals in simple (low viscous) liquids and saline solutions was observed for ²H, ⁷Li and ¹³C nuclei at ambient temperature. Substantial NMR signal enhancement up to several hundred was achieved for the studied samples. An advanced approach for reconstructing of the original relaxation dispersion of pure substances is used to eliminate the effect of the additional radical relaxivity of the X-nuclei.

Keywords: DNP; FFC; Hyperpolarization; NMR; Overhauser effect; TEMPO; X-nuclei.

Publication types

Research Support, Non-U.S. Gov't