Lack of clinical activity with crizotinib in a patient with FUS rearranged rhabdomyosarcoma with ALK protein overexpression

Pathology. 2019 Oct;51(6):655-657. doi: 10.1016/j.pathol.2019.07.004. Epub 2019 Aug 27.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Anaplastic Lymphoma Kinase / metabolism*
  • Antineoplastic Agents / administration & dosage*
  • Crizotinib / administration & dosage*
  • DNA-Binding Proteins / genetics
  • Gene Rearrangement*
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Positron Emission Tomography Computed Tomography
  • RNA-Binding Protein FUS / genetics*
  • Rhabdomyosarcoma / diagnostic imaging*
  • Rhabdomyosarcoma / genetics
  • Rhabdomyosarcoma / pathology
  • Sequence Analysis, DNA
  • Transcription Factors / genetics
  • Young Adult

Substances

  • Antineoplastic Agents
  • DNA-Binding Proteins
  • FUS protein, human
  • RNA-Binding Protein FUS
  • TFCP2 protein, human
  • Transcription Factors
  • Crizotinib
  • ALK protein, human
  • Anaplastic Lymphoma Kinase