Non-Viral Parasites Associated with Carcinogenesis

Cancer Invest. 2019;37(9):453-462. doi: 10.1080/07357907.2019.1662918. Epub 2019 Sep 13.

Abstract

Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by certain parasitic organisms other than viruses. This review tries to explore various less studied mechanisms by which these parasites induce cancer and lead to its progression. The changes brought by organisms in the genetic makeup are enumerated along with the effects of various protein products synthesised by these organisms.

Keywords: Cancer; Chlamydia; Cryptosporidium; Helicobacter; Opisthorchis; Schistosoma; inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Infections / complications*
  • Bacterial Infections / genetics
  • Carcinogenesis
  • Disease Progression
  • Gene Regulatory Networks
  • Humans
  • Mycoses / complications*
  • Mycoses / genetics
  • Neoplasms / etiology*
  • Neoplasms / genetics
  • Parasitic Diseases / complications*
  • Parasitic Diseases / genetics