Latest Advances on Bacterial Cellulose-Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Biotechnol J. 2019 Dec;14(12):e1900059. doi: 10.1002/biot.201900059. Epub 2019 Sep 17.

Abstract

Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state-of-the-art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

Keywords: bacterial cellulose; biomedical applications; drug delivery; regenerative medicine; wound healing.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / chemistry*
  • Biocompatible Materials / chemistry
  • Biomedical and Dental Materials
  • Bone Regeneration
  • Bridged Bicyclo Compounds, Heterocyclic
  • Cellulose / chemistry*
  • Drug Delivery Systems
  • Humans
  • Membranes, Artificial
  • Nanostructures
  • Polymers
  • Prostheses and Implants
  • Regenerative Medicine
  • Tissue Engineering*
  • Tissue Scaffolds / chemistry
  • Wound Healing*

Substances

  • Biocompatible Materials
  • Biomedical and Dental Materials
  • Bridged Bicyclo Compounds, Heterocyclic
  • Membranes, Artificial
  • Polymers
  • poly(3,4-ethylene dioxythiophene)
  • Cellulose