Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

Haibo Mei; Jianlin Han; Ryosuke Takeda; Tsubasa Sakamoto; Toshio Miwa; Yutaka Minamitsuji; Hiroki Moriwaki; Hidenori Abe; Vadim A Soloshonok

doi:10.1021/acsomega.9b01537

Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

ACS Omega. 2019 Jul 9;4(7):11844-11851. doi: 10.1021/acsomega.9b01537. eCollection 2019 Jul 31.

Authors

Affiliations

¹ College of Chemical Engineering Nanjing Forestry University, Nanjing 210037, China.
² Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
³ Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, San Sebastián 20018, Spain.
⁴ IKERBASQUE-Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, Bilbao 48013, Spain.

Abstract

This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.