Auric Chloride Induced Micellization on Fractal Patterned Dicationic Amphiphiles and Stabilization of Gold Nanoparticles

Thangavel Muthukumarasamyvel; Ganapathy Rajendran; Devendrapandi Santhana Panneer; Jayapalan Kasthuri; Krishnan Kathiravan; Nagappan Rajendiran

doi:10.1021/acsomega.7b00192

Auric Chloride Induced Micellization on Fractal Patterned Dicationic Amphiphiles and Stabilization of Gold Nanoparticles

ACS Omega. 2017 Jul 25;2(7):3539-3550. doi: 10.1021/acsomega.7b00192. eCollection 2017 Jul 31.

Authors

Thangavel Muthukumarasamyvel¹, Ganapathy Rajendran², Devendrapandi Santhana Panneer¹, Jayapalan Kasthuri³, Krishnan Kathiravan², Nagappan Rajendiran¹

Affiliations

¹ Department of Polymer Science, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India.
² Department of Biotechnology, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India.
³ Department of Chemistry, Quaid-E-Millath Government College for Women (Autonomous), Chennai 600002, Tamil Nadu, India.

Abstract

The present article reports the development of sunlight-mediated rapid synthesis of bile acid derived dicationic amphiphiles, namely, dicationic cysteamine-conjugated cholic acid (DCaC), dicationic cysteamine-conjugated deoxycholic acid (DCaDC), and dicationic cysteamine-conjugated lithocholic acid (DCaLC) by adopting thiol-yne click chemistry approach. The auric chloride (AuHCl₄) induced micellization of amphiphiles from fractal pattern to chainlike aggregates was examined by critical micelle concentration measurements, quenching studies, field emission scanning electron microscopy, and optical microscopy techniques. The micelles thus formed act as ideal templates for the stabilization of gold nanoparticles (AuNPs) and exhibit good stability for more than 6 months. The synthesized AuNPs were characterized using UV-visible spectroscopy, high-resolution transmission electron microscopy, DLS, zeta potential, and contact angle measurements. These NPs showed high salt tolerance, and the levels were found to be 420, 460, and 580 mM for DCaC-, DCaDC-, and DCaLC-capped AuNPs, respectively.