The relevance of Fas/Fas ligand axis in the tumor microenvironment of salivary gland adenoid cystic carcinoma

M Kuchar; Z Strizova; M Votava; J Plzak

doi:10.1016/j.oraloncology.2019.08.015

The relevance of Fas/Fas ligand axis in the tumor microenvironment of salivary gland adenoid cystic carcinoma

Oral Oncol. 2019 Oct:97:135-136. doi: 10.1016/j.oraloncology.2019.08.015. Epub 2019 Aug 24.

Authors

M Kuchar¹, Z Strizova², M Votava³, J Plzak³

Affiliations

¹ Department of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06 Prague 5, Czech Republic. Electronic address: martin.kuchar@fnmotol.cz.
² Department of Immunology, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06 Prague 5, Czech Republic.
³ Department of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06 Prague 5, Czech Republic.

PMID: 31455593
DOI: 10.1016/j.oraloncology.2019.08.015

No abstract available

Keywords: Adenoid cystic carcinoma; CD8 T cells; Checkpoint inhibitors; Fas ligand; Granzyme; PD-L1; Salivary gland carcinoma; Tumor microenvironment; Tumor-infiltrating lymphocytes.

Publication types

Letter

MeSH terms

Carcinoma, Adenoid Cystic / metabolism*
Fas Ligand Protein / metabolism*
Humans
Lymphocytes, Tumor-Infiltrating / metabolism
Salivary Gland Neoplasms / metabolism*
Salivary Glands / metabolism*
Tumor Microenvironment / physiology*
fas Receptor / metabolism*

Substances

FAS protein, human
FASLG protein, human
Fas Ligand Protein
fas Receptor