Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome

Carolina Balbi; Kirsten Lodder; Ambra Costa; Silvia Moimas; Francesco Moccia; Tessa van Herwaarden; Vittorio Rosti; Francesca Campagnoli; Agnese Palmeri; Pierangela De Biasio; Francesco Santini; Mauro Giacca; Marie-Josè Goumans; Lucio Barile; Anke M Smits; Sveva Bollini

doi:10.1016/j.dib.2019.104324

Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome

Data Brief. 2019 Jul 30:25:104324. doi: 10.1016/j.dib.2019.104324. eCollection 2019 Aug.

Authors

Carolina Balbi^{1

2}, Kirsten Lodder³, Ambra Costa¹, Silvia Moimas⁴, Francesco Moccia⁵, Tessa van Herwaarden³, Vittorio Rosti⁶, Francesca Campagnoli¹, Agnese Palmeri⁷, Pierangela De Biasio⁷, Francesco Santini⁸, Mauro Giacca⁴, Marie-Josè Goumans³, Lucio Barile², Anke M Smits³, Sveva Bollini¹

Affiliations

¹ Regenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.
² Molecular and Cell Cardiology Laboratory, CardioCentro Ticino, Lugano, Switzerland.
³ Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
⁴ Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
⁵ General Physiology Laboratory, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
⁶ Laboratory of Biochemistry, Biotechnology and Advanced Diagnostic, Myelofibrosis Study Centre, IRCCS Ospedale Policlinico San Matteo, Pavia, Italy.
⁷ Dept. of Obstetrics and Gynecology, Ospedale Policlinico San Martino - IRCCS per l'Oncologia, Genova, Italy.
⁸ Division of Cardiac Surgery, Ospedale Policlinico San Martino - IRCCS per l'Oncologia, Genova, Italy.

Abstract

The data and information presented here refer to the research article entitled: "Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting with the human amniotic fluid stem cell secretome" (Balbi et al., 2019, Apr 04). This dataset illustrates the in vitro paracrine effect exerted by the human amniotic fluid stem cell secretome on rodent neonatal cardiomyocytes, human endothelial progenitors and different subsets of cardiac progenitor cells. Cytokine/chemokine profiling of the human amniotic fluid stem cell secretome is provided as well. This data can provide useful insights in regenerative medicine as demonstrating the in vitro cardioprotective and proliferative secretory paracrine potential of human fetal stem cells.

Keywords: Angiogenesis; Cardiac progenitor cells; Cardioprotection; Endothelial progenitors; Human amniotic fluid stem cells; Neonatal cardiomyocytes; Paracrine effect; Proliferation.