Abstract
A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives were synthesized and fully characterized and in vitro tested against two strains of T. cruzi (NINOA and INC-5), exhibiting good activities at low concentrations.
Keywords:
Chagas disease; Trypanosoma cruzi; benzothiazole derivatives; neglected diseases; non-symmetric thioethers.
MeSH terms
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Benzothiazoles / chemistry*
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Chemistry Techniques, Synthetic
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Inhibitory Concentration 50
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Molecular Structure
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Parasitic Sensitivity Tests
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Structure-Activity Relationship
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Sulfides / chemistry*
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Sulfides / pharmacology*
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Trypanocidal Agents / chemistry*
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Trypanocidal Agents / pharmacology*
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Trypanosoma cruzi / drug effects
Substances
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Benzothiazoles
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Sulfides
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Trypanocidal Agents
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benzothiazole