Facile Synthesis of a Series of Non-Symmetric Thioethers Including a Benzothiazole Moiety and Their Use as Efficient In Vitro anti- Trypanosoma cruzi Agents

Molecules. 2019 Aug 24;24(17):3077. doi: 10.3390/molecules24173077.

Abstract

A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives were synthesized and fully characterized and in vitro tested against two strains of T. cruzi (NINOA and INC-5), exhibiting good activities at low concentrations.

Keywords: Chagas disease; Trypanosoma cruzi; benzothiazole derivatives; neglected diseases; non-symmetric thioethers.

MeSH terms

  • Benzothiazoles / chemistry*
  • Chemistry Techniques, Synthetic
  • Inhibitory Concentration 50
  • Molecular Structure
  • Parasitic Sensitivity Tests
  • Structure-Activity Relationship
  • Sulfides / chemistry*
  • Sulfides / pharmacology*
  • Trypanocidal Agents / chemistry*
  • Trypanocidal Agents / pharmacology*
  • Trypanosoma cruzi / drug effects

Substances

  • Benzothiazoles
  • Sulfides
  • Trypanocidal Agents
  • benzothiazole