Clinicopathological and prognostic significance of TINCR in caner: A meta-analysis

Sixuan Li; Juan Li; Hang Li; Min Gao; Na Li; Ying Wang; Lianwei Tong; Mingyang Song; Zhihua Yin

doi:10.1016/j.prp.2019.152596

Clinicopathological and prognostic significance of TINCR in caner: A meta-analysis

Pathol Res Pract. 2019 Oct;215(10):152596. doi: 10.1016/j.prp.2019.152596. Epub 2019 Aug 17.

Authors

Sixuan Li¹, Juan Li¹, Hang Li¹, Min Gao¹, Na Li¹, Ying Wang¹, Lianwei Tong¹, Mingyang Song¹, Zhihua Yin²

Affiliations

¹ Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
² Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: zhyin@cmu.edu.cn.

PMID: 31447059
DOI: 10.1016/j.prp.2019.152596

Abstract

Background: In a variety of cancers, the expression of TINCR is linked to the development, progression, metastasis, invasion, and prognosis of cancer. Our study is the first study used meta-analysis to explore the relationship between TINCR expression and cancer.

Methods: By looking up PubMed, Web of Science, CNKI database, we obtained 10 articles for analysis. The statistical analysis was all calculated by Stata 15.1 software.

Results: We found that the expression of TINCR was a risk factor to the size of the tumor (OR = 1.772, 95%CI: 1.246-2.520, P = 0.001). In univariate analysis, patients with high expression of TINCR had poor OS (pooled HR = 1.533, 95%CI: 1.025-2.294, P = 0.038). Similar result was also found in multivariate analysis In subgroup analysis (pooled HR = 1.610, 95%CI: 1.356-1.913, P = 0.000).We also found that over-expression of TINCR had poor OS in breast cancer (pooled HR = 1.582, 95%CI: 1.126-2.223, P = 0.008).

Conclusion: In this study, we found that over-expression of TINCR may influence the tumor size and contribute to the poor prognosis of cancer.

Keywords: Cancer; Long non coding RNA; Prognosis; TINCR.

Publication types

Meta-Analysis
Review

MeSH terms

Disease-Free Survival
Gene Expression Regulation, Neoplastic*
Humans
Neoplasms / genetics*
Neoplasms / mortality
Neoplasms / pathology
Prognosis
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding
TINCR lncRNA, human