Current Methods of Maxillofacial Tissue Engineering

James C Melville; Victoria A Mañón; Caleb Blackburn; Simon Young

doi:10.1016/j.coms.2019.07.003

Current Methods of Maxillofacial Tissue Engineering

Oral Maxillofac Surg Clin North Am. 2019 Nov;31(4):579-591. doi: 10.1016/j.coms.2019.07.003. Epub 2019 Aug 21.

Authors

James C Melville¹, Victoria A Mañón², Caleb Blackburn³, Simon Young⁴

Affiliations

¹ Oral, Head & Neck Oncology and Microvascular Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center, School of Dentistry, 6560 Fannin Street, Suite 1900, Houston, TX 77030, USA.
² Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center, School of Dentistry, 7500 Cambridge Street, Suite 6510, Houston, TX 77054, USA.
³ Department of Oral and Maxillofacial Surgery, University of Tennessee Medical Center, 1930 Alcoa Highway, Suite 335, Knoxville, TN 37920 USA.
⁴ Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center, School of Dentistry, 7500 Cambridge Street, Suite 6510, Houston, TX 77054, USA. Electronic address: Simon.Young@uth.tmc.edu.

PMID: 31445759
DOI: 10.1016/j.coms.2019.07.003

Abstract

For several decades, the multidisciplinary field of tissue engineering has striven to improve conventional methods of dental, oral, and craniofacial rehabilitation for millions of people annually. Several bone tissue engineering strategies are now readily available in the clinic. Enrichment of autologous products, growth factors, and combination approaches are discussed as ways to enhance the surgeon's traditional armamentarium. Lastly, cutting-edge research such as customized 3-dimensional printed bone scaffolds, tissue engineering strategies for volumetric muscle loss, and temporomandibular joint disc and condyle engineering are briefly discussed as future applications.

Keywords: Bone marrow aspirate concentrate (BMAC); Bone morphogenic protein (BMP); Composite allogeneic grafting; Platelet-rich fibrin (PRF); Platelet-rich plasma (PRP); Tissue engineering.

Publication types

Review

MeSH terms

Bone Regeneration / physiology*
Bone Transplantation / methods*
Fibrin / administration & dosage
Fibrin / metabolism*
Guided Tissue Regeneration, Periodontal / methods*
Humans
Platelet-Rich Plasma / physiology*
Surgery, Oral / methods*
Tissue Engineering*

Substances

Fibrin