Ameloblastic carcinoma: Clinicopathological analysis of 18 cases and a systematic review

Head Neck. 2019 Dec;41(12):4191-4198. doi: 10.1002/hed.25926. Epub 2019 Aug 24.

Abstract

Objectives: Exploring the clinicopathological features of ameloblastic carcinoma (AC) and reviewing the literature to improve the diagnosis and treatment of the disease.

Materials and methods: Clinical data and pathological features of 18 cases of AC were retrospectively analyzed. A systematic review was carried out by searching PubMed and Medline databases using the MeSH terms "ameloblastic" and "carcinoma."

Results: In the systematic analysis, 125 cases of AC from 81 eligible original studies and 18 cases of AC from this research were included. The male-to-female ratio was 2.58:1, and the mandible-to-maxilla ratio was 1.80:1. Mean age of patients was 45.3 years. Thirty-seven cases of recurrence and 27 cases of metastasis were recorded.

Conclusion: AC is a rare neoplasm of the odontogenic epithelium. A systematic review indicates that diagnoses at the early phase and a close periodic assessment for recurrence and metastasis are necessary.

Keywords: ameloblastic carcinoma; diagnosis; odontogenic tumor; pathology; survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Adult
  • Aged
  • Ameloblastoma / diagnosis
  • Ameloblastoma / mortality
  • Ameloblastoma / pathology*
  • Carcinoma / diagnosis
  • Carcinoma / mortality
  • Carcinoma / pathology*
  • Female
  • Humans
  • Male
  • Mandibular Neoplasms / diagnosis
  • Mandibular Neoplasms / mortality
  • Mandibular Neoplasms / pathology*
  • Maxillary Neoplasms / diagnosis
  • Maxillary Neoplasms / mortality
  • Maxillary Neoplasms / pathology*
  • Middle Aged
  • Neoplasm Metastasis / pathology
  • Neoplasm Recurrence, Local / pathology
  • Odontogenic Tumors / diagnosis
  • Odontogenic Tumors / mortality
  • Odontogenic Tumors / pathology*
  • Retrospective Studies
  • Survival Rate