Energy coupling in ABC exporters

Res Microbiol. 2019 Nov-Dec;170(8):392-398. doi: 10.1016/j.resmic.2019.08.003. Epub 2019 Aug 20.

Abstract

Multidrug transporters are important and interesting molecular machines that extrude a wide variety of cytotoxic drugs from target cells. This review summarizes novel insights in the energetics and mechanisms of bacterial ATP-binding cassette multidrug transporters as well as recent advances connecting multidrug transport to ion and lipid translocation processes in other membrane proteins.

Keywords: ABC transporter; Bioenergetics; Multidrug transport; Transport mechanisms.

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism*
  • Adenosine Triphosphate / metabolism
  • Anti-Bacterial Agents / metabolism*
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / metabolism*
  • Biological Transport / physiology
  • Drug Resistance, Multiple, Bacterial / physiology*
  • Energy Metabolism / physiology*
  • Protein Conformation

Substances

  • ATP-Binding Cassette Transporters
  • Anti-Bacterial Agents
  • Adenosine Triphosphate