We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.
Keywords: Aspergillus fumigatus; CT; France; Rhizomucor; acute myeloid leukemia; antimicrobial resistance; aspergillosis; computed tomography; death; fungal co-infection; fungi; galactomannan antigen; graft-versus-host disease; hematopoietic stem-cell transplantation; immunocompromised patients; invasive fungal disease; isavuconazole; mucormycosis; qPCR; quantitative PCR; treatment failure.