Toxicological Potential of Cadmium Impact on Rainbow Trout (Oncorhynchus mykiss) in Early Development

Bull Environ Contam Toxicol. 2019 Oct;103(4):544-550. doi: 10.1007/s00128-019-02694-y. Epub 2019 Aug 22.

Abstract

Cadmium (Cd) is a toxic element widely distributed in the aquatic environment and producing a wide variety of harmful effects. In this study, the acute toxicity (96 h LC50) of Cd to rainbow trout Oncorhynchus mykiss embryos and larvae was determined. The obtained results showed that hatched larvae were the most sensitive to Cd exposure. After 4 days of exposure, embryos were found to have accumulated greater concentrations of Cd than larvae. Exposure to Cd at sublethal concentrations produced deleterious, exposure duration-related effects on biological parameters (mortality, heart rate and gill ventilation frequency) of larvae. Cd induced a significant elevation of all the studied geno- and cytotoxicity endpoints in larval erythroblasts.

Keywords: Accumulation; Biological parameters; Cytotoxicity; Early development stages; Genotoxicity; Metallothionein.

MeSH terms

  • Animals
  • Cadmium / analysis
  • Cadmium / toxicity*
  • Embryo, Nonmammalian / chemistry
  • Embryo, Nonmammalian / drug effects*
  • Gills / drug effects
  • Heart Rate / drug effects
  • Larva / chemistry
  • Larva / drug effects*
  • Lethal Dose 50
  • Oncorhynchus mykiss / growth & development
  • Oncorhynchus mykiss / physiology*
  • Water Pollutants, Chemical / analysis
  • Water Pollutants, Chemical / toxicity*

Substances

  • Water Pollutants, Chemical
  • Cadmium