In insects that undergo complete metamorphosis, cell death is essential for reshaping or removing larval tissues and organs, thus contributing to formation of the adult's body structure. In the last few decades, the study of metamorphosis in Lepidoptera and Diptera has provided broad information on the tissue remodelling processes that occur during larva-pupa-adult transition and made it possible to unravel the underlying regulatory pathways. This review summarizes recent knowledge on cell death mechanisms in Lepidoptera and other holometabolous insects, highlighting similarities and differences with Drosophila melanogaster, and discusses the role of apoptosis and autophagy in this developmental setting. This article is part of the theme issue 'The evolution of complete metamorphosis'.
Keywords: Lepidoptera; apoptosis; autophagy; metamorphosis; programmed cell death.