Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations

Jonathan Tersur Orasugh; Soumyadip Dutta; Diphankar Das; Chandrika Pal; Aisha Zaman; Sreyasi Das; Koushik Dutta; Rajdeb Banerjee; Swapan Kumar Ghosh; Dipankar Chattopadhyay

doi:10.1016/j.ijbiomac.2019.08.143

Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations

Int J Biol Macromol. 2019 Nov 1:140:441-453. doi: 10.1016/j.ijbiomac.2019.08.143. Epub 2019 Aug 19.

Affiliations

¹ Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, West Bengal, India; Department of Jute and Fiber Technology, Institute of Jute Technology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, West Bengal, India; Center for Research in Nanoscience and Nanotechnology, Acharya Prafulla Chandra Roy Sikhsha Prangan, University of Calcutta, JD-2, Sector-III, Saltlake City, Kolkata 700 098, WB, India.
² Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, West Bengal, India.
³ Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, WB, India.
⁴ Department of Jute and Fiber Technology, Institute of Jute Technology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, West Bengal, India.
⁵ Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, West Bengal, India. Electronic address: dipankar.chattopadhyay@gmail.com.

PMID: 31437512
DOI: 10.1016/j.ijbiomac.2019.08.143

Abstract

There has been extensive utilization of poloxamer 407 (PM) for the delivery of various ophthalmic drugs aimed at efficient ophthalmic drug delivery approach for longer precorneal residence time along with acceptable bioavailability of drugs. We have studied the effect of nanocellulose grafted collagen (CGC) on the performance of in situ gels based on PM for the controlled in vitro release of Ketorolac Tromethamine (KT). CGC has shown great influence evident by the reduction in PM critical gelation concentration, increased gel strength, and prolonged the release of loaded drugs compared with the virgin PM gel. The engineered nanocomposite formulations established an anomalous diffusion mechanism along with a Fickian diffusion controlled drug release for 1.5 & 1.75 w/v% CGC reinforced PM. Hence, the synthesized in situ nanocomposites are potential candidates for ophthalmic drug delivery system.

Keywords: Cellulose nanofibrils; Collagen; Grafting; Rheology; Sustained ophthalmic drug delivery.

MeSH terms

Cell Line
Cellulose / chemical synthesis
Cellulose / chemistry*
Cellulose / pharmacology
Collagen / chemical synthesis
Collagen / chemistry
Collagen / therapeutic use
Drug Compounding
Drug Delivery Systems*
Drug Liberation
Humans
Ketorolac Tromethamine / chemical synthesis
Ketorolac Tromethamine / chemistry
Nanofibers / chemistry*
Nanofibers / therapeutic use
Ophthalmic Solutions / chemical synthesis
Ophthalmic Solutions / chemistry*
Ophthalmic Solutions / therapeutic use
Poloxamer / chemistry
Rheology

Substances

Ophthalmic Solutions
Poloxamer
Ketorolac Tromethamine
Cellulose
Collagen