mSphere of Influence: the Importance of Metabolism for Pathogen Adaptation to Host-Imposed Stresses

Jorge Amich

doi:10.1128/mSphere.00566-19

mSphere of Influence: the Importance of Metabolism for Pathogen Adaptation to Host-Imposed Stresses

mSphere. 2019 Aug 21;4(4):e00566-19. doi: 10.1128/mSphere.00566-19.

Author

Jorge Amich¹

Affiliation

¹ Manchester Fungal Infection Group (MFIG), Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom jorge.amichelias@manchester.ac.uk.

Abstract

Jorge Amich studies several aspects of sulfur and nitrogen metabolism in Aspergillus fumigatus, with the ultimate aim of identifying targets for the development of novel antifungals. In this mSphere of Influence article, he reflects on how "Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis" (A. McDonagh, N. D. Fedorova, J. Crabtree, Y. Yu, S. Kim, et al., PLoS Pathog 4:e1000154, 2008, https://doi.org/10.1371/journal.ppat.1000154) impacted his thinking about in vivo metabolism and how to investigate it.

Keywords: fungal virulence; in vivo transcriptomics.

Publication types

Personal Narrative

MeSH terms

Adaptation, Physiological*
Antifungal Agents / pharmacology
Aspergillosis / microbiology
Aspergillus fumigatus / metabolism*
Aspergillus fumigatus / pathogenicity*
Host-Pathogen Interactions*
Secondary Metabolism
Virulence

Substances

Antifungal Agents

Grants and funding

MR/N008707/1/MRC_/Medical Research Council/United Kingdom