[Differentiation of prostatitis and clinically significant prostate cancer in peripheral zone using the prostate imaging-reporting and data system]

T H Zhang; C H Hu; J X Chen; Z D Xu; Y J Hu; H F Cai; L P Shen

doi:10.3760/cma.j.issn.0376-2491.2019.31.010

[Differentiation of prostatitis and clinically significant prostate cancer in peripheral zone using the prostate imaging-reporting and data system]

Zhonghua Yi Xue Za Zhi. 2019 Aug 20;99(31):2455-2458. doi: 10.3760/cma.j.issn.0376-2491.2019.31.010.

[Article in Chinese]

Authors

T H Zhang¹, C H Hu², J X Chen¹, Z D Xu¹, Y J Hu¹, H F Cai¹, L P Shen¹

Affiliations

¹ Department of Radiology, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang 215600, China.
² Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

PMID: 31434427
DOI: 10.3760/cma.j.issn.0376-2491.2019.31.010

Abstract
in English, Chinese

Objective: To determine whether clinically significant prostate cancer (PCa) and prostatitis in the peripheral zone can be distinguished using prostate imaging reporting and data system version 1 (PI-RADS V1) and version 2(PI-RADS V2). Methods: Between September 2010 and August 2016, mpMRI data of 77 patients with PCa and 29 prostatitis obtained at 3.0 T were collected in Zhangjiagang Hospital Affiliated to Soochow University. Every lesion was scored according to PI-RADS (V1 and V2), as well as a sum score and a PI-RADS V2 score. The non-parametric Kruskal-Wallis test was used to assess differences between PCa and prostatitis regarding PS3, PS4 and PI-RADS V2 score. The diagnostic performance of PI-RADS V1 and V2 for detection of prostatitis in peripheral zone was compared by analyzing ROC curve. Results: The PI-RADS V1 score for PS3, PS4 and the PI-RADS V2-score were all significantly higher for PCa (PS3:12.1±2.1; PS4:16.2±2.9; V2:4.6±0.8) than for prostatitis (PS3:8.0±0.7; PS4:10.6±1.0; V2:3.0±0.5) (all P<0.01). Of these parameters, PS4 achieved the highest predictive value for the presence of prostatitis with an AUC of 0.937, sensitivity and specificity were 87.0%, 97.0% with a threshold of 12.5. Conclusion: Prostatitis can be differentiated from clinically significant PCa in peripheral zone on mpMRI using PI-RADS system, PS4 achieved better results compared to PS3 and V2.

目的： 探讨第一版和第二版前列腺影像报告和数据系统（PI-RADS）鉴别外周带前列腺炎和临床显著前列腺癌的临床价值。 方法： 回顾性分析2010年9月至2016年8月在苏州大学附属张家港医院经病理证实的77例外周带临床显著前列腺癌及29例外周带前列腺炎病例的T(2)WI、扩散加权成像（DWI）、动态增强（DCE）及磁共振波谱成像（MRS）资料，分别对每一个病灶进行PI-RADS V1、PI-RADS V2评分，并计算PI-RADS V1中三个参数（PS3：T(2)WI+DWI+DCE）、四个参数（PS4：T(2)WI+DWI+DCE+MRS）的总分。比较PS3、PS4以及PI-RADS V2在外周带临床显著前列腺癌与外周带前列腺炎评分之间的差异。以病理结果为标准，评价PS3、PS4及PI-RADS V2评分对外周带前列腺炎的诊断效能。 结果： 外周带前列腺癌组的PS3、PS4总分以及PI-RADS V2评分分别为（12.1±2.1）、（16.2±2.9）、（4.6±0.8）分，外周带前列腺炎组的PS3、PS4总分以及PI-RADS V2评分分别为（8.0±0.7）、（10.6±1.0）、（3.0±0.5）分；外周带前列腺癌组的PS3、PS4总分以及PI-RADS V2评分均显著高于外周带前列腺炎（均P<0.01）。在这些参数中，PS4诊断前列腺炎的效能最高（AUC=0.937），各组间曲线下面积差异均无统计学意义（均P>O.05）。PS4使用最佳诊断阈值为12.5时，其敏感度最高为87.0%，特异度为97.0%。 结论： PI-RADS V1和V2对外周带临床显著前列腺癌与前列腺炎具有很好的鉴别诊断能力。.

Keywords: Comparative study; Magnetic resonance imaging; Prostatic neoplasms; Prostatitis.

MeSH terms

Data Systems
Humans
Magnetic Resonance Imaging
Male
Prostatic Neoplasms*
Prostatitis*
Retrospective Studies

Grants and funding

2017YFC0114300/National Key R&D Program of China "Jiangsu digital innovation diagnosis and treatment equipment demonstration study"

Abstract in English, Chinese

MeSH terms

Grants and funding

Abstract
in English, Chinese