B Cells Hit a Class Ceiling in the Germinal Center

Lucy Cooper; Kim L Good-Jacobson

doi:10.1016/j.immuni.2019.07.004

B Cells Hit a Class Ceiling in the Germinal Center

Immunity. 2019 Aug 20;51(2):206-208. doi: 10.1016/j.immuni.2019.07.004.

Authors

Lucy Cooper¹, Kim L Good-Jacobson²

Affiliations

¹ Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
² Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia. Electronic address: kim.jacobson@monash.edu.

PMID: 31433966
DOI: 10.1016/j.immuni.2019.07.004

Abstract

Class-switch recombination (CSR) provides diverse effector functions to B cells. In this issue of Immunity, Roco et al. (2019) refute long-standing dogma that germinal centers are the principal location for CSR; instead, CSR predominantly occurs early post immunization and declines during germinal center formation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

B-Lymphocytes
Germinal Center*
Immunoglobulin Class Switching*