Necrotizing fasciitis associated with sorafenib treatment

Ho Won Kang; Seok-Joong Yun; Wun-Jae Kim

doi:10.1016/j.idcr.2019.e00611

Necrotizing fasciitis associated with sorafenib treatment

IDCases. 2019 Jul 27:18:e00611. doi: 10.1016/j.idcr.2019.e00611. eCollection 2019.

Authors

Ho Won Kang^{1

2}, Seok-Joong Yun^{1

2}, Wun-Jae Kim^{1

2}

Affiliations

¹ Department of Urology, College of Medicine, Chungbuk National University, Cheongju, South Korea.
² Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea.

Abstract

We present here a case of extensive necrotizing fasciitis during sorafenib treatment in a patient with HBV-related hepatocellular carcinoma. Despite emergent extensive surgical debridement, the patient's clinical status progressive worsened until interruption of sorafenib therapy. The patient was successfully treated with temporal interruption of sorafenib therapy. To our knowledge, this is the first case report of sorafenib-associated necrotizing fasciitis. Given the life-threatening nature of the infection and the necessity for urgent intervention, clinicians should be aware of this possible adverse effect of tyrosine kinase inhibitors.

Keywords: Adverse drug reaction; Hepatocellular carcinoma; Necrotizing fasciitis; Tyrosine kinase inhibitors.

Publication types

Case Reports