Anticoagulation is indicated in most cases of venous thromboembolism
Monotherapy with rivaroxaban or apixaban is the preferred option for most adults with acute venous thromboembolism
There are no recommended dose reductions for rivaroxaban or apixaban in venous thromboembolism, unlike for atrial fibrillation
The initial duration of anticoagulation is usually three months
Extended treatment with low-dose rivaroxaban or apixaban is effective in preventing recurrence in patients with a continuing increased risk of thromboembolism. Both drugs have low rates of major bleeding
Keywords: anticoagulants; apixaban; rivaroxaban; venous thromboembolism; warfarin.