Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Frank Weinberg; Nithya Ramnath; Deepak Nagrath

doi:10.3390/cancers11081191

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Cancers (Basel). 2019 Aug 16;11(8):1191. doi: 10.3390/cancers11081191.

Authors

Frank Weinberg¹, Nithya Ramnath^{1

2}, Deepak Nagrath^{3

4

5}

Affiliations

¹ Division of Hematology and Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
² VA Ann Arbor Health Care System, Ann Arbor, MI 48109, USA.
³ Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. dnagrath@umich.edu.
⁴ Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA. dnagrath@umich.edu.
⁵ Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. dnagrath@umich.edu.

Abstract

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity.

Keywords: ROS; metabolism; mitochondria; stroma; tissue infiltrating lymphocytes; tumor microenvironment; tumorigenesis.

Publication types

Review

Abstract

Publication types

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