Abstract
SUMOylation and DeSUMOylation are reversible protein post-translational modification (PTM) processes involving small ubiquitin-like modifier (SUMO) proteins. These processes have indispensable roles in various cellular processes, such as subcellular localization, gene transcription, and DNA replication and repair. Over the past decade, increasing attention has been given to SUMO-related pathways as potential therapeutic targets. The Sentrin/SUMO-specific protease (SENP), which is responsible for deSUMOylation, has been proposed as a potential therapeutic target in the treatment of cancers and cardiac disorders. Unfortunately, no SENP inhibitor has yet reached clinical trials. In this review, we focus on advances in the development of SENP inhibitors in the past decade.
MeSH terms
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Animals
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Cardiovascular Diseases / enzymology
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Cardiovascular Diseases / genetics
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Cardiovascular Diseases / metabolism*
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Cell Cycle Checkpoints / genetics
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Cysteine Endopeptidases / chemistry
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Cysteine Endopeptidases / genetics
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Cysteine Endopeptidases / metabolism*
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Cysteine Proteinase Inhibitors / chemistry*
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Cysteine Proteinase Inhibitors / metabolism
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Humans
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Molecular Targeted Therapy
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Neoplasms / enzymology
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Neoplasms / genetics
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Neoplasms / metabolism*
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Protein Domains / genetics
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Protein Processing, Post-Translational / genetics
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Small Ubiquitin-Related Modifier Proteins / chemistry
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Small Ubiquitin-Related Modifier Proteins / genetics
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Small Ubiquitin-Related Modifier Proteins / metabolism*
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Sumoylation*
Substances
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Cysteine Proteinase Inhibitors
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Small Ubiquitin-Related Modifier Proteins
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SENP1 protein, human
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Cysteine Endopeptidases