Old T Cells Interfer(on) with Neurogenesis

Justin Rustenhoven; Jasmin Herz; Jonathan Kipnis

doi:10.1016/j.it.2019.07.007

Old T Cells Interfer(on) with Neurogenesis

Trends Immunol. 2019 Sep;40(9):783-785. doi: 10.1016/j.it.2019.07.007. Epub 2019 Aug 15.

Authors

Justin Rustenhoven¹, Jasmin Herz², Jonathan Kipnis³

Affiliations

¹ Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: Jjr9na@virginia.edu.
² Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
³ Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: kipnis@virginia.edu.

PMID: 31422900
DOI: 10.1016/j.it.2019.07.007

Abstract

Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.

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MeSH terms

Adult
Brain
Humans
Neurogenesis
Single-Cell Analysis*
T-Lymphocytes*