β Cell Senescence as a Common Contributor to Type 1 and Type 2 Diabetes

Yan Tian; Yuwei Zhang; Xianghui Fu

doi:10.1016/j.molmed.2019.07.009

β Cell Senescence as a Common Contributor to Type 1 and Type 2 Diabetes

Trends Mol Med. 2019 Sep;25(9):735-737. doi: 10.1016/j.molmed.2019.07.009. Epub 2019 Aug 15.

Authors

Yan Tian¹, Yuwei Zhang², Xianghui Fu³

Affiliations

¹ Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China.
² Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
³ Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China. Electronic address: xfu@scu.edu.cn.

PMID: 31422036
DOI: 10.1016/j.molmed.2019.07.009

Abstract

Type 1 (T1D) and type 2 diabetes (T2D), two distinct clinical entities principally driven by autoimmunity and metabolic dysfunction, respectively, are associated with β cell failure. Two studies (Thompson et al., Cell Metab., 2019 and Aguayo-Mazzucato et al., Cell Metab., 2019) now reveal a role for β cell senescence in T1D and T2D, and highlight the potential of senolytic therapy for these diseases.

Keywords: Bcl-2; aging; diabetes; senescence; senolysis; β cell.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Autoimmunity
Cellular Senescence*
Diabetes Mellitus, Type 1 / etiology*
Diabetes Mellitus, Type 1 / metabolism
Diabetes Mellitus, Type 2 / etiology*
Diabetes Mellitus, Type 2 / metabolism
Disease Susceptibility
Humans
Insulin-Secreting Cells / immunology
Insulin-Secreting Cells / metabolism*
Insulin-Secreting Cells / pathology