Imaging the Hepatitis B Virus: Broadcasting Live

Maika S Deffieu; Raphael Gaudin

doi:10.1016/j.tim.2019.07.007

Imaging the Hepatitis B Virus: Broadcasting Live

Trends Microbiol. 2019 Oct;27(10):810-813. doi: 10.1016/j.tim.2019.07.007. Epub 2019 Aug 14.

Authors

Maika S Deffieu¹, Raphael Gaudin²

Affiliations

¹ Institut de Recherche en Infectiologie de Montpellier, CNRS, Univ Montpellier, 34293 Montpellier, France.
² Institut de Recherche en Infectiologie de Montpellier, CNRS, Univ Montpellier, 34293 Montpellier, France. Electronic address: raphael.gaudin@irim.cnrs.fr.

PMID: 31421968
DOI: 10.1016/j.tim.2019.07.007

Abstract

Although important breakthroughs in our understanding of the hepatitis B virus (HBV) life cycle have been made since the discovery of its main entry factor, the spatiotemporal dynamics of HBV-host interactions remains understudied. Here, we discuss recent advances and continuing challenges to image the HBV life cycle in live cells.

Keywords: high-resolution microscopy; intracellular trafficking; live cell imaging; spatiotemporal dynamics; virus entry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hep G2 Cells
Hepatitis B / virology
Hepatitis B virus / physiology*
Host-Pathogen Interactions / physiology*
Humans
Life Cycle Stages
Microscopy
Virus Internalization