Biodegradation of antibiotics: The new resistance determinants - part II

Ana C Reis; Boris A Kolvenbach; Olga C Nunes; Philippe F X Corvini

doi:10.1016/j.nbt.2019.08.003

Biodegradation of antibiotics: The new resistance determinants - part II

N Biotechnol. 2020 Jan 25:54:13-27. doi: 10.1016/j.nbt.2019.08.003. Epub 2019 Aug 13.

Authors

Ana C Reis¹, Boris A Kolvenbach², Olga C Nunes³, Philippe F X Corvini⁴

Affiliations

¹ Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132, Muttenz, Switzerland; LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, Department of Chemical Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.
² Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132, Muttenz, Switzerland. Electronic address: boris.kolvenbach@fhnw.ch.
³ LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, Department of Chemical Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal. Electronic address: opnunes@fe.up.pt.
⁴ Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132, Muttenz, Switzerland.

PMID: 31419608
DOI: 10.1016/j.nbt.2019.08.003

Abstract

Antibiotic residues are widespread in the environment and their presence is known to contribute to the propagation of antibiotic resistance. Nevertheless, knowledge on processes involved in their degradation is scattered. This second part of a two part review aims at compiling knowledge on the (bio-) degradation of antibiotics, focusing on β-lactams, macrolides, quinolones and ionophores, as well as some less common classes. Detailed metabolic and molecular aspects are discussed, as well as the role of antibiotic degraders in natural microbial communities. This exercise led to the conclusion that among the classes analyzed, the majority of antibiotics are prone to microbial cleavage or transformation.

Keywords: Antibiotics; B-lactams; Biodegradation; Ionophore antibiotics; Macrolides; Quinolones; Subsistence; Transformation.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / analysis
Anti-Bacterial Agents / metabolism*
Anti-Bacterial Agents / pharmacology
Biodegradation, Environmental
Drug Resistance, Microbial* / drug effects
Humans

Substances

Anti-Bacterial Agents