The SUF system: an ABC ATPase-dependent protein complex with a role in Fe-S cluster biogenesis

Pierre Simon Garcia; Simonetta Gribaldo; Béatrice Py; Frédéric Barras

doi:10.1016/j.resmic.2019.08.001

The SUF system: an ABC ATPase-dependent protein complex with a role in Fe-S cluster biogenesis

Res Microbiol. 2019 Nov-Dec;170(8):426-434. doi: 10.1016/j.resmic.2019.08.001. Epub 2019 Aug 14.

Authors

Pierre Simon Garcia¹, Simonetta Gribaldo², Béatrice Py³, Frédéric Barras⁴

Affiliations

¹ Department of Microbiology, Stress Adaptation and Metabolism in Enterobacteria Unit, ERL CNRS 6002, Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France; Department of Microbiology, Evolutionary Biology of the Microbial Cell Unit, Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France.
² Department of Microbiology, Evolutionary Biology of the Microbial Cell Unit, Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France.
³ Laboratoire de Chimie Bactérienne, UMR7243 Aix-Marseille Université CNRS, 31 Chemin Joseph Aiguier, 13009, Marseille, France. Electronic address: py@imm.cnrs.fr.
⁴ Department of Microbiology, Stress Adaptation and Metabolism in Enterobacteria Unit, ERL CNRS 6002, Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France. Electronic address: fbarras@pasteur.fr.

PMID: 31419582
DOI: 10.1016/j.resmic.2019.08.001

Abstract

Iron-sulfur (Fe-S) clusters are considered one of the most ancient and versatile inorganic cofactors present in the three domains of life. Fe-S clusters can act as redox sensors or catalysts and are found to be used by a large number of functional and structurally diverse proteins. Here, we cover current knowledge of the SUF multiprotein machinery that synthesizes and inserts Fe-S clusters into proteins. Specific focus is put on the ABC ATPase SufC, which contributes to building Fe-S clusters, and appeared early on during evolution.

Keywords: Iron-sulfur biogenesis; Iron-sulfur cluster; P-loop ATPase; Suf proteins; SufBCD complex.

Publication types

Review

MeSH terms

ATP-Binding Cassette Transporters / metabolism*
Adenosine Triphosphatases / metabolism*
Carrier Proteins / metabolism*
Escherichia coli / metabolism*
Escherichia coli Proteins / metabolism*
Iron / metabolism
Iron-Sulfur Proteins / metabolism*
Proton-Translocating ATPases / metabolism*
Sulfur / metabolism

Substances

ATP-Binding Cassette Transporters
Carrier Proteins
Escherichia coli Proteins
Iron-Sulfur Proteins
SufB protein, E coli
SufD protein, E coli
Sulfur
Iron
Adenosine Triphosphatases
SufC protein, E coli
Proton-Translocating ATPases