JAK2 exon 12 mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis: Not an exclusive mutation to polycythaemia vera

Br J Haematol. 2019 Oct;187(1):e27-e31. doi: 10.1111/bjh.16146. Epub 2019 Aug 16.

Authors

Affiliations

¹ Department of Haematology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
² Department of Transfusion Medicine and Stem Cell Regulation, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
³ Leading Centre for the Development and Research of Cancer Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
⁴ Department of Pathology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan.

PMID: 31418453
DOI: 10.1111/bjh.16146

No abstract available

Keywords: JAK2 exon 12 mutation; MDS/MPN-RS-T; clonal architecture; myelodysplastic syndrome; myeloproliferative neoplasm.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sideroblastic / genetics
Anemia, Sideroblastic / pathology
Humans
Janus Kinase 2 / genetics*
Mutation*
Myelodysplastic-Myeloproliferative Diseases / genetics*
Myelodysplastic-Myeloproliferative Diseases / pathology
Phosphoproteins / genetics
Polycythemia Vera / genetics*
Polycythemia Vera / pathology
RNA Splicing Factors / genetics
Thrombocytosis / genetics
Thrombocytosis / pathology
Tumor Stem Cell Assay

Substances

Phosphoproteins
RNA Splicing Factors
SF3B1 protein, human
JAK2 protein, human
Janus Kinase 2