Objective: To explore the significance of lymphocyte to monocyte ratio (LMR) in the disease progress of primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL).
Methods: The clinical data of 43 patients diagnosed as PGI-DLBCL in our hospital from January 2011 to December 2015 were collected, and the disease progress was followed up.
Results: According to the ROC curve, the threshold value of LMR for 2 years PFS (%) of PGI-DLBCL patients was 2.6. Unvariate analysis showed that LMR (P＜0.05), large enclosed mass lesion (P＜0.01) and IPI (P＜0.05) were prognostic factors affecting PFS, the COX regression model multivariate analysis showed that LMR＜2.6 [ (risk ratio (RR)=3.083, 95%CI 1.828-8.313, P＜0.01], and large enclosed mass lesions (RR=2.718, 95%CI 1.339-6.424, P＜0.05) were the independent adverse prognostic factor for two years PFS.
Conclusion: Both LMR＜2.6 and large enclosed mass lesions relate with the progress of PGI-DLBCL.
题目: 外周血淋巴细胞与单核细胞比值在PGI-DLBCL疾病进展中的意义.
目的: 探讨外周血淋巴细胞与单核细胞比值（lymphocyte to monocyte ratio，LMR）在原发胃肠道弥漫性大B细胞淋巴瘤（primary gastrointestinal diffuse large B cell lymphoma，PGI-DLBCL）疾病进展中的意义.
方法: 收集本院2011年1月至2015年12月期间经病理学确诊为PGI-DLBCL的43例患者的临床资料，并随访观察患者疾病进展情况,分析LMR与患者2年PFS（%）之间的关系.
结果: 根据ROC曲线PGI-DLBCL患者LMR最具差异性的界限值为2.6。单因素分析显示，LMR（P＜0.05）、大包块病变（P＜0.01)和IPI（P＜0.05)为影响患者2年PFS（%）的预后因素。COX回归模型多因素分析显示，LMR＜2.6 [（危险比（RR）=3.083，95%CI 1.828-8.313，P＜0.01）]、大包块病变（RR=2.718，95%CI 1.339-6.424 ，P＜0.05）为2年PFS（%）的不良预后相关因素.
结论: LMR＜2.6，大包块病变与PGI-DLBCL患者疾病的进展相关.