Fundamentals of Clinical Prediction Modeling for the Neurosurgeon

Neurosurgery. 2019 Sep 1;85(3):302-311. doi: 10.1093/neuros/nyz282.

Abstract

Clinical prediction models in neurosurgery are increasingly reported. These models aim to provide an evidence-based approach to the estimation of the probability of a neurosurgical outcome by combining 2 or more prognostic variables. Model development and model reporting are often suboptimal. A basic understanding of the methodology of clinical prediction modeling is needed when interpreting these models. We address basic statistical background, 7 modeling steps, and requirements of these models such that they may fulfill their potential for major impact for our daily clinical practice and for future scientific work.

Keywords: Aneurysmal subarachnoid hemorrhage; Clinical prediction; Model development; Neurosurgery; Outcome; Risk assessment.

MeSH terms

  • Decision Support Techniques*
  • Evidence-Based Medicine / methods*
  • Humans
  • Neurosurgeons*
  • Neurosurgery*
  • Neurosurgical Procedures
  • Probability
  • Prognosis