Data on the stability of Prx1-associated snRNAs and mRNAs

Eun-Kyung Kim; Sung-Min Ahn; Ho Hee Jang

doi:10.1016/j.dib.2019.104309

Data on the stability of Prx1-associated snRNAs and mRNAs

Data Brief. 2019 Jul 25:25:104309. doi: 10.1016/j.dib.2019.104309. eCollection 2019 Aug.

Authors

Eun-Kyung Kim¹, Sung-Min Ahn^{2

3}, Ho Hee Jang^{1

4}

Affiliations

¹ Department of Biochemistry, College of Medicine, Gachon University, Incheon, 21999, Republic of Korea.
² Department of Genome Medicine and Science, College of Medicine, Gachon University, Incheon, 21936, Republic of Korea.
³ Division of Medical Oncology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, 21565, Republic of Korea.
⁴ Department of Health Sciences and Technology, Graduate School of Medicine, Gachon University, Incheon, 21999, Republic of Korea.

Abstract

This data set is related to the research article entitled "Peroxiredoxin 1 post-transcriptionally regulates snoRNA expression" (Kim et al., 2019). It demonstrates that peroxiredoxin 1 (Prx1) increases the stability of Prx1-associated small nuclear RNAs (snRNAs) and mRNAs. We overexpressed Prx1 in SNU484 and HeLa cells, which were then treated with Actinomycin D (ActD) to inhibit transcription. After that, we measured the levels of Prx1-associated snRNAs and mRNAs using qPCR analysis.

Keywords: Peroxiredoxin1; Protein-RNA interaction; RNA stability; Small nuclear RNA.