Pleiotropy Complicates Human Gene Editing: CCR5Δ32 and Beyond

Front Genet. 2019 Jul 30:10:669. doi: 10.3389/fgene.2019.00669. eCollection 2019.

Ting Li¹, Xia Shen^{1

2

3}

¹ Biostatistics Group, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen Univeristy, Guangzhou, China.
² Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
³ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

No abstract available

Keywords: CCR5Δ32; CRISPR; UK Biobank; autoimmune disease; cardiovascular disease; gene editing; pleiotropy.