Skin immunity and its dysregulation in psoriasis

Caterina Lanna; Mara Mancini; Roberta Gaziano; Maria Vittoria Cannizzaro; Marco Galluzzo; Marina Talamonti; Valentina Rovella; Margherita Annicchiarico-Petruzzelli; Gerry Melino; Ying Wang; Yufang Shi; Elena Campione; Luca Bianchi

doi:10.1080/15384101.2019.1653099

Skin immunity and its dysregulation in psoriasis

Cell Cycle. 2019 Oct;18(20):2581-2589. doi: 10.1080/15384101.2019.1653099. Epub 2019 Aug 15.

Authors

Affiliations

¹ Unit of Dermatology, Department of Systems Medicine, University of Rome 'Tor Vergata' , Rome , Italy.
² Biochemistry Laboratory, Istituto Dermopatico Immacolata (IDI-IRCCS) , Rome , Italy.
³ Department of Experimental Medicine, TOR, University of Rome Tor Vergata , Rome , Italy.
⁴ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences/Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai , China.
⁵ The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College , Suzhou , Jiangsu , 215123 , China.

Abstract

The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.

Keywords: Psoriasis; biologic therapies; cytokines; immunity; lymphocytes.

Publication types

Review

MeSH terms

Animals
Cytokines / antagonists & inhibitors
Cytokines / chemistry
Cytokines / immunology
Humans
Immunity, Innate*
Mice
Molecular Targeted Therapy / methods
Psoriasis / drug therapy
Psoriasis / immunology*
Psoriasis / pathology*
Skin / immunology*
T-Lymphocytes / immunology

Substances

Cytokines

Grants and funding

This work has been supported by the Medical Research Council (to GM), Associazione Italiana per la Ricerca contro il Cancro (AIRC) to GM [IG#20473 (2018-2022)], Fondazione Luigi Maria Monti IDI-IRCCS (R.C. to M.M., M.A.P, G.M.), Ministry of Health & MAECI Italy-China Science and Technology Cooperation [#PGR00961] cooperation grant. Work has been also supported by Regione Lazio through LazioInnova Progetto Gruppo di Ricerca n [85-2017-14986].