Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models

Xin Zhang; Yanling Liu; Jinwen Qi; Zhengzhi Tian; Ni Tang; Defang Chen; Zhiqiong Li

doi:10.1016/j.peptides.2019.170124

Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models

Peptides. 2019 Nov:121:170124. doi: 10.1016/j.peptides.2019.170124. Epub 2019 Aug 12.

Authors

Xin Zhang¹, Yanling Liu², Jinwen Qi², Zhengzhi Tian², Ni Tang², Defang Chen², Zhiqiong Li³

Affiliations

¹ Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China; The Key Laboratory of Mariculture, Ministry of Education, Fisheries College, Ocean University of China, 5# Yushan Road, Qingdao, Shandong, China.
² Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China.
³ Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China. Electronic address: lizhiqiong454@163.com.

PMID: 31415798
DOI: 10.1016/j.peptides.2019.170124

Abstract

Urocortin3 (UCN3), the newest member of corticotrophin releasing hormone (CRH) family polypeptides, is an anorexic factor discovered in 2001, which has a strong inhibitory effect on animal appetite regulation. UCN3 is widely distributed in various tissues of animals and has many biological functions. Based on the research progress of UCN3 on mammals and non-mammals, this paper summarized the discovery, tissue distribution, appetite regulation and mechanism of UCN3 in animals, in order to provide a reference for feeding regulation and growth in mammals and fish in further research and production.

Keywords: Appetite factor; Appetite regulation; Food intake; Urocortin3 (UCN3).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adrenocorticotropic Hormone / genetics*
Adrenocorticotropic Hormone / metabolism
Animals
Appetite / genetics*
Appetite Regulation / genetics*
Chickens
Cholecystokinin / genetics
Cholecystokinin / metabolism
Gastric Emptying / genetics*
Gene Expression Regulation
Ghrelin / genetics
Ghrelin / metabolism
Humans
Mice
Neuropeptide Y / genetics
Neuropeptide Y / metabolism
Pro-Opiomelanocortin / genetics
Pro-Opiomelanocortin / metabolism
Rats
Receptors, Corticotropin-Releasing Hormone / genetics
Receptors, Corticotropin-Releasing Hormone / metabolism
Signal Transduction / genetics
Urocortins / genetics*
Urocortins / metabolism
Xenopus laevis
Zebrafish

Substances

CRF receptor type 2
Ghrelin
Neuropeptide Y
Receptors, Corticotropin-Releasing Hormone
Urocortins
Pro-Opiomelanocortin
Adrenocorticotropic Hormone
Cholecystokinin