Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid

Leo C James; Till Böcking

doi:10.1016/j.chom.2019.07.011

Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid

Cell Host Microbe. 2019 Aug 14;26(2):151-153. doi: 10.1016/j.chom.2019.07.011.

Authors

Leo C James¹, Till Böcking²

Affiliations

¹ Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom. Electronic address: lcj@mrc-lmb.cam.ac.uk.
² EMBL Australia Node in Single Molecule Science and ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, UNSW, Sydney, Australia. Electronic address: till.boecking@unsw.edu.au.

PMID: 31415744
DOI: 10.1016/j.chom.2019.07.011

Abstract

In this issue of Cell Host & Microbe, Summers et al. (2019) use protein engineering to generate a toolbox of HIV-1 capsid oligomers. In an accompanying Cell Reports paper, Huang et al. (2019) use these oligomers to determine how the capsid engages the kinesin-1 adaptor protein FEZ1.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing
Capsid Proteins
Capsid*
HIV-1*
Kinesins

Substances

Adaptor Proteins, Signal Transducing
Capsid Proteins
Kinesins

Grants and funding

MC_U105181010/MRC_/Medical Research Council/United Kingdom