MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug

Aline Alfaro; Andrea León; Emanuel Guajardo-Correa; Patricia Reúquen; Francisco Torres; Mario Mery; Rodrigo Segura; Paula A Zapata; Pedro A Orihuela

doi:10.1371/journal.pone.0214900

MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug

PLoS One. 2019 Aug 15;14(8):e0214900. doi: 10.1371/journal.pone.0214900. eCollection 2019.

Authors

Aline Alfaro^{1

2}, Andrea León^{2

3}, Emanuel Guajardo-Correa^{1

2}, Patricia Reúquen^{1

2}, Francisco Torres⁴, Mario Mery⁵, Rodrigo Segura⁶, Paula A Zapata⁷, Pedro A Orihuela^{1

2}

Affiliations

¹ Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
² Centro para el Desarrollo de la Nanociencia y la Nanotecnología CEDENNA, Santiago, Chile.
³ Max Planck Institute for Chemical Physics of Solids, D-01068 Dresden, Germany.
⁴ Departamento de Física, Facultad de Ciencias Naturales, Universidad de Atacama, Copayapu 485, Copiapó, Chile.
⁵ Centro Científico Tecnológico de Valparaíso-CCTVal, Universidad Técnica Federico Santa María, Valparaíso, Chile.
⁶ Instituto de Química y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.
⁷ Grupo Polímeros, Facultad de Química Biología, Universidad de Santiago de Chile, Santiago, Chile.

Abstract

Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Methoxyestradiol / chemistry*
2-Methoxyestradiol / pharmacology
Absorption, Physicochemical
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Drug Carriers / chemistry*
Drug Carriers / toxicity
Drug Liberation
Humans
Kinetics
Magnesium Oxide / chemistry*
Magnesium Oxide / toxicity
Models, Molecular
Molecular Conformation
Nanoparticles / chemistry*
Polyethylene Glycols / chemistry*

Substances

Antineoplastic Agents
Drug Carriers
Magnesium Oxide
Polyethylene Glycols
2-Methoxyestradiol

Grants and funding

This work received financial support from grants DICYT 021743OD-DAS and Basal Program for Centers of Excellence, Grant FB0807 CEDENNA, CONICYT and the DGIIP-USM. Proyecto Basal FB0821 – CONICYT. P.A. Zapata acknowledges the financial support of FONDECYT Regular N 1170226. A. León acknowledges the financial support of CONICYT Becas Chile Postdoctorado Grant No. 74190099.