Asymmetric Synthesis and Stereochemical Assignment of 12C/13C Isotopomers

Tomoya Miura; Takayuki Nakamuro; Yuuya Nagata; Daisuke Moriyama; Scott G Stewart; Masahiro Murakami

doi:10.1021/jacs.9b07181

Asymmetric Synthesis and Stereochemical Assignment of ¹²C/¹³C Isotopomers

J Am Chem Soc. 2019 Aug 28;141(34):13341-13345. doi: 10.1021/jacs.9b07181. Epub 2019 Aug 19.

Authors

Tomoya Miura¹, Takayuki Nakamuro¹, Yuuya Nagata¹, Daisuke Moriyama¹, Scott G Stewart¹, Masahiro Murakami¹

Affiliation

¹ Department of Synthetic Chemistry and Biological Chemistry , Kyoto University , Katsura, Kyoto 615-8510 , Japan.

PMID: 31408332
DOI: 10.1021/jacs.9b07181

Abstract

A synthesis of chiral hydrocarbons having C₁ axis and C₃ symmetry, which owe their chirality due to asymmetrical distribution of ¹²C/¹³C isotopes, is reported. Their absolute configurations assigned using the vibrational circular dichroism technique conform with those deduced from the absolute configurations of the parent α-formyl cyclopropanes.

Publication types

Research Support, Non-U.S. Gov't