Pharmacokinetics and Penetration of Sitafloxacin into Alveolar Epithelial Lining Fluid in Critically Ill Thai Patients with Pneumonia

Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00800-19. doi: 10.1128/AAC.00800-19. Print 2019 Oct.

Abstract

Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0-8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.).

Keywords: critically ill patients; epithelial lining fluid; pharmacokinetics; sitafloxacin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use*
  • Bronchoalveolar Lavage / methods
  • Bronchoalveolar Lavage Fluid
  • Critical Illness
  • Female
  • Fluoroquinolones / pharmacokinetics*
  • Fluoroquinolones / therapeutic use*
  • Humans
  • Lung / drug effects
  • Lung / microbiology
  • Macrophages, Alveolar / drug effects*
  • Macrophages, Alveolar / metabolism
  • Male
  • Middle Aged
  • Pneumonia / drug therapy*
  • Pneumonia / metabolism
  • Respiratory Mucosa / drug effects*
  • Respiratory Mucosa / microbiology
  • Thailand

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • sitafloxacin

Associated data

  • TCTR/TCTR20170222001