Spread of NDM-5 and OXA-181 Carbapenemase-Producing Escherichia coli in Chad

Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00646-19. doi: 10.1128/AAC.00646-19. Print 2019 Nov.

Abstract

We detected for the first time blaNDM-5 and blaOXA-181 in Escherichia coli isolates from hospitalized patients and healthy volunteers in Chad. These resistance genes were located on IncX3 and IncF plasmids. Despite the large diversity of E. coli clones, the identified resistant intestinal isolates belonged mainly to the same sequence type.

Keywords: Chad; Escherichia coli; carbapenemases; clinical samples; fecal carriage prevalence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Carbapenem-Resistant Enterobacteriaceae / genetics
  • Chad
  • Enterobacteriaceae Infections / drug therapy
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / microbiology
  • Escherichia coli Proteins / genetics*
  • Humans
  • Microbial Sensitivity Tests / methods
  • Plasmids / genetics
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Escherichia coli Proteins
  • beta lactamase NDM-5, E coli
  • beta-Lactamases
  • beta-lactamase OXA-181, E coli
  • carbapenemase