Association between Dietary Intake and Lipid-Lowering Therapy: Prospective Analysis of Data from Australian Diabetes, Obesity, and Lifestyle Study (AusDiab) Using a Quantile Regression Approach

Nutrients. 2019 Aug 9;11(8):1858. doi: 10.3390/nu11081858.

Abstract

Lipid-lowering therapy (LLT) should be accompanied by dietary guidance for cardiovascular risk reduction; however, current evidence suggests sub-optimal dietary behaviors in those on LLT. We examined the associations between the dietary intake of key food groups (vegetables, fruit, cereal, protein, and dairy) and LLT use in Australian adults using quantile regression. We used data from the Australian Diabetes, Obesity and Lifestyle Study (AusDiab), a prospective population-based study of adults aged ≥25 years, conducted over 5 years (1999-2005). Measurements included a 121-item food frequency questionnaire and LLT use. LLT use was categorized as: LLT users (n = 446), commenced LLT (n = 565), ceased LLT (n = 71), and non-users (n = 4813). Less than 1% of the cohort met recommended intakes of all food groups at the baseline and follow up. The median daily dietary intake at the follow up among LLT users was 2.2 serves of vegetables, 1.4 serves of fruit, 2.8 serves of cereal, 2.0 serves of protein, and 1.4 serves of dairy. Adjusted analysis showed no differences across the quantiles of intake of key food groups in LLT users and commenced LLT compared to non-users. The LLT medication status is not associated with any difference in meeting recommended intakes of key foods.

Keywords: cardiovascular disease; cereal; dairy; food groups; fruit; lipid-lowering therapy; protein; quantile regression; statins; vegetable.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Australia / epidemiology
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / prevention & control*
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Dietary Fats / administration & dosage*
  • Dietary Fats / adverse effects
  • Dietary Fats / blood
  • Dyslipidemias / blood
  • Dyslipidemias / diagnosis
  • Dyslipidemias / drug therapy*
  • Dyslipidemias / epidemiology
  • Female
  • Humans
  • Hypolipidemic Agents / adverse effects
  • Hypolipidemic Agents / therapeutic use*
  • Male
  • Middle Aged
  • Nutritive Value
  • Obesity / epidemiology
  • Prospective Studies
  • Recommended Dietary Allowances
  • Risk Factors
  • Risk Reduction Behavior*
  • Time Factors
  • Treatment Outcome

Substances

  • Dietary Fats
  • Hypolipidemic Agents