The role of kisspeptin system in cancer biology

Martha Stathaki; Maria Evanthia Stamatiou; George Magioris; Spyridon Simantiris; Nikolaos Syrigos; Spyridon Dourakis; Michael Koutsilieris; Athanasios Armakolas

doi:10.1016/j.critrevonc.2019.07.015

The role of kisspeptin system in cancer biology

Crit Rev Oncol Hematol. 2019 Oct:142:130-140. doi: 10.1016/j.critrevonc.2019.07.015. Epub 2019 Aug 3.

Authors

Martha Stathaki¹, Maria Evanthia Stamatiou¹, George Magioris¹, Spyridon Simantiris¹, Nikolaos Syrigos¹, Spyridon Dourakis², Michael Koutsilieris¹, Athanasios Armakolas³

Affiliations

¹ Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece.
² 2nd Academic Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens School of Medicine Hippokration General Hospital Athens Greece, Greece.
³ Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: aarmakol@med.uoa.gr.

PMID: 31401420
DOI: 10.1016/j.critrevonc.2019.07.015

Abstract

Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their antimetastatic activities in several malignancies. Herein we report recent evidence of the role of kisspeptins in cancer biology and we examine the prospective of targeting the kisspeptin pathways leading to a better prognosis in patients with malignant diseases.

Keywords: Cancer; KiSS-1; KiSS-1R; Kisspeptin; Metastases inhibition.

Publication types

Review

MeSH terms

Animals
Female
Humans
Kisspeptins / metabolism*
Male
Neoplasms / metabolism*
Receptors, Kisspeptin-1 / metabolism
Signal Transduction*

Substances

KISS1 protein, human
Kisspeptins
Receptors, Kisspeptin-1