Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis

Haematologica. 2020 Apr;105(4):e153-e156. doi: 10.3324/haematol.2018.210799. Epub 2019 Aug 8.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Erythroblasts / metabolism
  • Gene Deletion
  • Hemolysis
  • Janus Kinase 2 / genetics
  • Janus Kinase 2 / metabolism
  • Mice
  • MicroRNAs / genetics*
  • Mutation
  • Oxidative Stress / genetics
  • Polycythemia Vera* / genetics
  • Polycythemia* / genetics

Substances

  • MicroRNAs
  • Mirn451 microRNA, mouse
  • Jak2 protein, mouse
  • Janus Kinase 2